一.臨床意義

C肽（C-Peptide）又稱連接肽，是胰島β細胞的分泌產物，它與胰島素有一個共同的前體—胰島素原。一個分子的胰島素原經酶切后，裂解成一個分子的胰島素和一個分子的C肽。正常情況下，人胰島細胞主要分泌產生并釋放到血液中的是胰島素，在產生胰島素的一系列的過程中，胰島細胞首先合成胰島素原。胰島素原是一條很長的蛋白質鏈，胰島素原在酶的作用下被分解為三段，前后兩段又重新聯接，成為有A鏈和B鏈組成的胰島素，中間一段獨立出來，稱為C肽。

C肽與胰島素以等分子數共存于分泌顆粒并同時釋放至毛細血管循環中，且C肽不被肝臟破壞，半壽期較胰島素明顯為長，故測定血循環中c肽水平能反映β細胞合成與釋放胰島素功能。C肽的測定，有助于糖尿病的臨床分型，胰島細胞瘤的診斷及判斷胰島素瘤手術效果,判定患者的胰島β細胞功能，鑒別低血糖的原因等。測定血清C肽的水平可以了解胰島的分泌、代謝和胰島B細胞的儲備功能。

二.參考文獻

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